Mitochondria-targeted colorimetric and fluorescent probes for hypochlorite and their applications for in vivo imaging.
نویسندگان
چکیده
Two mitochondria-targeted real-time probes were presented, which could selectively respond to hypochlorite over other ROS. Meanwhile, the "off-on" probes could be successfully applied in the in vivo imaging of hypochlorite in living mice.
منابع مشابه
I-55: Molecular Imaging Overview
Molecular imaging is the noninvasive visualization of normal as well as abnormal cellular processes at a molecular or genetic level of function. It is used to provide characterization and measurement of biological processes in living animals and humans (in vivo). The discipline of molecular imaging evolved rapidly over the past decade through the integration of cell biology, molecular biology a...
متن کاملA fast-responsive mitochondria-targeted fluorescent probe detecting endogenous hypochlorite in living RAW 264.7 cells and nude mouse.
A very fast-responsive fluorescent probe PZ-Py for imaging mitochondrial HClO/ClO(-), with a relatively long emission wavelength, was prepared. The limit of detection was evaluated to be 17.9 nM. Moreover, the probe PZ-Py was successfully applied in the imaging of endogenous HClO/ClO(-) in the mitochondria of RAW 264.7 cells and living nude mouse.
متن کاملApplication of FITC for detecting the binding of antiangiogenic peptide to HUVECs
Angiogenesis is the generation of new blood vessels from the existing vasculature. The angiogenic programme requires the degradation of the basement membrane, endothelial cell migration and invasion of the extracellular matrix, with endothelial cell proliferation and capillary lumen formation before maturation and stabilization of the new vasculature. Angiogenesis is dependent on a delicate equ...
متن کاملComparative Studies of High Contrast Fluorescence Imaging Efficiency of Silica-coated CdSe Quantum Dots with Green and Red Emission
Herein we report the possibility of using green and red emitting silica-coated cadmium selenide (CdSe) quantum dots (QDs) for remarkable stem and cancer cellular imaging, efficient cellular uptake and fluorescence imaging of semi and ultra-thin sections of tumor for in vivo tumor targeted imaging applications. The comparative studies of high contrast cellular imaging behaviours of the silica-co...
متن کاملHydrophobic analogues of rhodamine B and rhodamine 101: potent fluorescent probes of mitochondria in living C. elegans
Mitochondria undergo dynamic fusion and fission events that affect the structure and function of these critical energy-producing cellular organelles. Defects in these dynamic processes have been implicated in a wide range of human diseases including ischemia, neurodegeneration, metabolic disease, and cancer. To provide new tools for imaging of mitochondria in vivo, we synthesized novel hydropho...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Chemical communications
دوره 50 63 شماره
صفحات -
تاریخ انتشار 2014